Whole body physiologically based modelling of β-blockers in the rat: events in tissues and plasma following an i.v. bolus dose.

@article{Cheung2018WholeBP,
  title={Whole body physiologically based modelling of β-blockers in the rat: events in tissues and plasma following an i.v. bolus dose.},
  author={Shirley Y.Y. Cheung and Tyler Rodgers and Leon Aarons and Ivelina Gueorguieva and Gemma L. Dickinson and S Murby and Charlotte L. Brown and Bill Collins and Malcolm Rowland},
  journal={British journal of pharmacology},
  year={2018},
  volume={175 1},
  pages={
          67-83
        }
}
BACKGROUND AND PURPOSE Whole body physiologically based pharmacokinetic (PBPK) models have been increasingly applied in drug development to describe kinetic events of therapeutic agents in animals and humans. The advantage of such modelling is the ability to incorporate vast amounts of physiological information, such as organ blood flow and volume, to ensure that the model is as close to reality as possible. EXPERIMENTAL APPROACH Previous PBPK model development of enantiomers of a series of… CONTINUE READING

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