Whole body leptin kinetics and renal metabolism in vivo.

  title={Whole body leptin kinetics and renal metabolism in vivo.},
  author={Jianbo Zeng and Bruce W. Patterson and Samuel Klein and Daniel Rodr{\'i}guez Mart{\'i}n and Samuel Dagogo-Jack and Wendy M. Kohrt and Steven B. Miller and Michael L Landt},
  journal={The American journal of physiology},
  volume={273 6 Pt 1},
Leptin metabolism was investigated in male Sprague-Dawley rats by use of 125I-labeled leptin plasma kinetic and arteriovenous balance studies. When conscious rats received bolus venous injections of 125I-leptin, intact (precipitable) leptin quickly disappeared from circulation in a biexponential manner during the 2-h experimental period. After substantial delay, most of the injected radioactivity appeared in the urine. The data were described by a two-compartment model, which postulated that… CONTINUE READING


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