Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.

@article{Shankaran2005WholebodyHF,
  title={Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.},
  author={Seetha Shankaran and Abbot R. Laptook and Richard A. Ehrenkranz and Jon E. Tyson and Scott A McDonald and Edward F. Donovan and Avroy A. Fanaroff and William Kenneth Poole and Linda L. Wright and Rosemary D. Higgins and Neil Norman Finer and Waldemar A. Carlo and Shahnaz Duara and William Oh and Charles Michael Cotten and David K. Stevenson and Barbara J. Stoll and James A Lemons and Ronnie Guillet and Alan Hall Jobe},
  journal={The New England journal of medicine},
  year={2005},
  volume={353 15},
  pages={1574-84}
}
BACKGROUND Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia in term infants with encephalopathy is uncertain. METHODS We conducted a randomized trial of hypothermia in infants with a gestational age of at least 36 weeks who were admitted to the hospital at or before six hours of age with either severe acidosis or perinatal complications and resuscitation at birth and who had moderate or severe… CONTINUE READING
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