Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.

@article{Steinberg2010WholeBD,
  title={Whole body deletion of AMP-activated protein kinase \{beta\}2 reduces muscle AMPK activity and exercise capacity.},
  author={Gregory R Steinberg and Hayley M O'Neill and Nicolas L Dzamko and Sandra Galic and Tim Naim and Ren{\'e} Koopman and Sebastian Beck J\orgensen and Jane E. Honeyman and Kimberly Kappler Hewitt and Z P Chen and Jonathan D Schertzer and John W Scott and Frank Koentgen and Gordon S Lynch and Matthew J Watt and Bryce J. W. van Denderen and Duncan J. Campbell and Bruce E. Kemp},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 48},
  pages={37198-209}
}
AMP-activated protein kinase (AMPK) β subunits (β1 and β2) provide scaffolds for binding α and γ subunits and contain a carbohydrate-binding module important for regulating enzyme activity. We generated C57Bl/6 mice with germline deletion of AMPK β2 (β2 KO) and examined AMPK expression and activity, exercise capacity, metabolic control during muscle contractions, aminoimidazole carboxamide ribonucleotide (AICAR) sensitivity, and susceptibility to obesity-induced insulin resistance. We find that… CONTINUE READING
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