Whole body cholesterol metabolism is impaired in Huntington's disease.

@article{Leoni2011WholeBC,
  title={Whole body cholesterol metabolism is impaired in Huntington's disease.},
  author={Valerio Leoni and Caterina Mariotti and Lorenzo Nanetti and Elena Salvatore and Ferdinando Squitieri and Anna Rita Bentivoglio and Monica Bandettini di Poggio and Silvia Piacentini and Daniela Monza and Marta Valenza and Elena Cattaneo and Stefano Di Donato},
  journal={Neuroscience letters},
  year={2011},
  volume={494 3},
  pages={245-9}
}
We previously reported impaired cholesterol biosynthesis in rodent Huntington Disease (HD) models and HD patients' fibroblasts and post mortem brains. We also found that plasma levels of 24S-hydroxycholesterol (24OHC), the brain specific elimination product of cholesterol considered a marker of brain cholesterol turnover, were significantly reduced in HD patients at any disease stage. In the present study we analysed by mass spectrometry the fasting plasma levels of cholesterol, its… CONTINUE READING