Whole body and regional retention of99mTc-labeled pyrophosphate at 24 hours: Physiological basis of the method for assessing the metabolism of bone in disease

@article{Martin1983WholeBA,
  title={Whole body and regional retention of99mTc-labeled pyrophosphate at 24 hours: Physiological basis of the method for assessing the metabolism of bone in disease},
  author={Patrick P Martin and Andr{\'e} Schoutens and D M Manicourt and Pierre Bergmann and Michel Fuss and M. Verbanck},
  journal={Calcified Tissue International},
  year={1983},
  volume={35},
  pages={37-42}
}
The retention of99mTc-labeled pyrophosphate (PPi) at 24 h was measured in 235 patients, 119 of whom had a normal bone metabolism. The mean retention in the group of normal subjects is 52% of the injected dose. Reproducibility of the measurement in a given person is 5.5% coefficient of variation (CV). The value depends strongly on sex (higher in males) and age (higher with increasing age, especially in cortical bone). Retention increases slowly with the decrease in glomerular filtration rate… CONTINUE READING

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