Whole blood transcriptome analysis reveals potential competition in metabolic pathways between negative energy balance and response to inflammatory challenge

@inproceedings{BouvierMuller2017WholeBT,
  title={Whole blood transcriptome analysis reveals potential competition in metabolic pathways between negative energy balance and response to inflammatory challenge},
  author={Juliette Bouvier-Muller and Charlotte Allain and Guillaume Tabouret and Francis Enjalbert and David Ferreira Portes and C{\'e}line Noirot and Roland Dr Rupp and Gilles Foucras},
  booktitle={Scientific Reports},
  year={2017}
}
Negative Energy Balance (NEB) is considered to increase susceptibility to mastitis. The objective of this study was to improve our understanding of the underlying mechanisms by comparing transcriptomic profiles following NEB and a concomitant mammary inflammation. Accordingly, we performed RNA-seq analysis of blood cells in energy-restricted ewes and control-diet ewes at four different time points before and after intra mammary challenge with phlogogenic ligands. Blood leucocytes responded to… CONTINUE READING
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