Whole-blood serotonin in premenstrual syndrome.

  title={Whole-blood serotonin in premenstrual syndrome.},
  author={Andrea J. Rapkin and E Edelmuth and Li-Jui Chang and Anthony E. Reading and M T Mcguire and T P Su},
  journal={Obstetrics and gynecology},
  volume={70 4},
Whole-blood serotonin levels in 14 subjects with well documented premenstrual syndrome and 13 age-matched controls were compared. Serotonin levels of premenstrual syndrome subjects were significantly lower during the last ten days of the menstrual cycle. No significant differences were noted in levels of serum estradiol and progesterone. Decreased serotonin is known to be associated with depression in humans, and nonhuman primates have exhibited abnormal behavioral profiles when given serotonin… CONTINUE READING