Whole animal modeling: piecing together nematode locomotion

@article{Cohen2019WholeAM,
  title={Whole animal modeling: piecing together nematode locomotion},
  author={Netta Cohen and Jack E. Denham},
  journal={Current Opinion in Systems Biology},
  year={2019}
}

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References

SHOWING 1-10 OF 102 REFERENCES
Nematode locomotion: dissecting the neuronal–environmental loop
A simulation model of the locomotion controllers for the nematode Caenorhabditis elegans
TLDR
This model is sufficiently rich to generate patterns of undulations that are reminiscent of the biological worm's behaviour and qualitatively similar to patterns which have been shown to generate locomotion in a model of a richer physical environment.
An Integrated Neuromechanical Model of Steering in C. elegans
TLDR
Analysis of the sensorimotor transformation and phasic stimulation experiments provides evidence that the principles of operation for steering discussed in the model are relevant for steering in the worm.
Gait Modulation in C. elegans: An Integrated Neuromechanical Model
TLDR
A model of C. elegans forward locomotion is presented that includes a neuromuscular control system that relies on a sensory feedback mechanism to generate undulations and is integrated with a physical model of the body and environment and reproduces the entire swim-crawl transition with no modulatory mechanism.
Systems level circuit model of C. elegans undulatory locomotion: mathematical modeling and molecular genetics
TLDR
The model reveals that stretch receptor coupling in the body wall is critical for generation of the neuromuscular wave, and agrees with behavioral data and with other pertinent published data, e.g., that frequency is an increasing function of muscle gap-junction coupling.
Neurobiology of Caenorhabditis elegans Locomotion: Where Do We Stand?
TLDR
The nematode Caenorhabditis elegans is used for detailed studies of genetic and physiological locomotion mechanisms, and locomotion behavior, the parts constituting the locomotion system, and the relevant neuronal connectivity are described.
From head to tail: a neuromechanical model of forward locomotion in Caenorhabditis elegans
  • E. Izquierdo, R. Beer
  • Medicine, Biology
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2018
TLDR
Analysis of the development and analysis of a model of forward locomotion that integrates the neuroanatomy, neurophysiology and body mechanics of the worm revealed that head motoneurons SMD and RMD are sufficient to drive dorsoventral undulations in the head and neck and that short-range posteriorly directed proprioceptive feedback is sufficient to propagate the wave along the rest of the body.
Low-dimensional functionality of complex network dynamics: neurosensory integration in the Caenorhabditis Elegans connectome.
TLDR
The first full dynamic model of the neural voltage excitations that allows for a characterization of network structures which link input stimuli to neural proxies of behavioral responses is posit, showing that robust, low-dimensional bifurcation structures drive neural voltage activity modes.
A new computational method for a model of C. elegans biomechanics: Insights into elasticity and locomotion performance
TLDR
This work forms a biomechanical model of C. elegans locomotion as a nonlinear initial-boundary value problem which allows the study of the dynamics of arbitrary body shapes, undulation gaits and the link between the animal's material properties and its performance across a range of environments.
The neural basis of the locomotion of nematodes
A model of electrotonic neurons is presented which allows computer simulation of a physiologically realistic neural network, such as that found in nematodes. The undulatory locomotion of
...
1
2
3
4
5
...