Whole-Genome Sequencing of Three Clonal Clinical Isolates of B. cenocepacia from a Patient with Cystic Fibrosis.

@article{Miller2015WholeGenomeSO,
  title={Whole-Genome Sequencing of Three Clonal Clinical Isolates of B. cenocepacia from a Patient with Cystic Fibrosis.},
  author={R. Reuben Miller and Trevor J. Hird and Patrick Tang and James E A Zlosnik},
  journal={PloS one},
  year={2015},
  volume={10 11},
  pages={
          e0143472
        }
}
Burkholderia cepacia complex bacteria are amongst the most feared of pathogens in cystic fibrosis (CF). The BCC comprises at least 20 distinct species that can cause chronic and unpredictable lung infections in CF. Historically the species B. cenocepacia has been the most prevalent in CF infections and has been associated in some centers with high rates of mortality. Modeling chronic infection by B. cenocepacia in the laboratory is challenging and no models exist which effectively recapitulate… CONTINUE READING
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