Whole-Genome Sequencing Reveals Diverse Models of Structural Variations in Esophageal Squamous Cell Carcinoma.

  title={Whole-Genome Sequencing Reveals Diverse Models of Structural Variations in Esophageal Squamous Cell Carcinoma.},
  author={Caixia Cheng and Yong Zhou and Hongyi Li and Teng Xiong and Shuai Cheng Li and Yanghui Bi and Pengzhou Kong and Fang Wang and Heyang Cui and Yaoping Li and Xiaodong Fang and Ting Liang Yan and Yike Li and Juan Wang and Bin Yang and Ling Zhang and Zhiwu Jia and Bin Song and Xiaoling Hu and Jie Yang and Haile Qiu and Gehong Zhang and Jing Liu and Enwei Xu and Ruyi Shi and Yanyan Zhang and Haiyan Liu and Chanting He and Zhenxiang Zhao and Yu Qian and Ruizhou Rong and Zhiwei Han and Yanlin Zhang and Wen Luo and Jiaqian Wang and Shaoliang Peng and Xukui Yang and Xiangchun Li and Lin Li and Hu Jin Fang and Xingmin Liu and Li Ma and Yunqing Chen and Shiping Guo and Xing C. Chen and Yan-feng Xi and Guodong Li and Jianfang Liang and Xiaofeng Yang and Jiansheng Guo and Junmei Jia and Qing-Shan Li and Xiaolong Cheng and Qimin Zhan and Yongping Cui},
  journal={American journal of human genetics},
  volume={98 2},
Comprehensive identification of somatic structural variations (SVs) and understanding their mutational mechanisms in cancer might contribute to understanding biological differences and help to identify new therapeutic targets. Unfortunately, characterization of complex SVs across the whole genome and the mutational mechanisms underlying esophageal squamous cell carcinoma (ESCC) is largely unclear. To define a comprehensive catalog of somatic SVs, affected target genes, and their underlying… CONTINUE READING
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