Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types

@inproceedings{Amend2015WholeGS,
  title={Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types},
  author={Sarah R. Amend and William C. Wilson and Liang C. Chu and Lan Lu and Pengyuan Y Liu and Daniel J. Serie and Xinming Su and Yalin Xu and Dingyan Wang and Anthony O Gramolini and Xiao-Yan Wen and Julie O’Neal and Michelle A. Hurchla and Celine M. Vachon and Graham C Colditz and Ravi Vij and Katherine N. Weilbaecher and Michael H. Tomasson and Claire M Edwards},
  booktitle={PloS one},
  year={2015}
}
Monoclonal gammopathy of undetermined significance (MGUS) is the requisite precursor to multiple myeloma (MM), a malignancy of antibody-producing plasma B-cells. The genetic basis of MGUS and its progression to MM remains poorly understood. C57BL/KaLwRij (KaLwRij) is a spontaneously-derived inbred mouse strain with a high frequency of benign idiopathic paraproteinemia (BIP), a phenotype with similarities to MGUS including progression to MM. Using mouse haplotype analysis, human MM SNP array… CONTINUE READING
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