Whole-Genome Patterns of Common DNA Variation in Three Human Populations

@article{Hinds2005WholeGenomePO,
  title={Whole-Genome Patterns of Common DNA Variation in Three Human Populations},
  author={D. Hinds and L. Stuve and Geoffrey B. Nilsen and E. Halperin and E. Eskin and D. Ballinger and K. Frazer and D. Cox},
  journal={Science},
  year={2005},
  volume={307},
  pages={1072 - 1079}
}
Individual differences in DNA sequence are the genetic basis of human variability. We have characterized whole-genome patterns of common human DNA variation by genotyping 1,586,383 single-nucleotide polymorphisms (SNPs) in 71 Americans of European, African, and Asian ancestry. Our results indicate that these SNPs capture most common genetic variation as a result of linkage disequilibrium, the correlation among common SNP alleles. We observe a strong correlation between extended regions of… Expand
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