Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype.

@article{Chen2016WholeGD,
  title={Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype.},
  author={Yung-Che Chen and Ting-Wen Chen and Mao-Chang Su and Chung-Jen Chen and Kuang-Den Chen and C W Liou and Petrus Tang and Ting-Ya Wang and Jen-Chieh Chang and Chin-Chou Wang and Hsin-Ching Lin and Chien-Hung Chin and Kuo-Tung Huang and Meng-Chih Lin and Chang-Chun Hsiao},
  journal={Sleep},
  year={2016},
  volume={39 4},
  pages={
          743-55
        }
}
STUDY OBJECTIVES We hypothesized that DNA methylation patterns may contribute to disease severity or the development of hypertension and excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea (OSA). METHODS Illumina's (San Diego, CA, USA) DNA methylation 27-K assay was used to identify differentially methylated loci (DML). DNA methylation levels were validated by pyrosequencing. A discovery cohort of 15 patients with OSA and 6 healthy subjects, and a validation cohort of… CONTINUE READING

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