Whole-Genome Analysis of Human Influenza A Virus Reveals Multiple Persistent Lineages and Reassortment among Recent H3N2 Viruses

@article{Holmes2005WholeGenomeAO,
  title={Whole-Genome Analysis of Human Influenza A Virus Reveals Multiple Persistent Lineages and Reassortment among Recent H3N2 Viruses},
  author={Edward C. Holmes and Elodie Ghedin and Naomi F. Miller and Jill Fairhurst Taylor and Yīm{\'i}ng B{\`a}o and Kirsten St George and Bryan T. Grenfell and Steven L Salzberg and Claire M. Fraser and David J. Lipman and Jeffery K. Taubenberger},
  journal={PLoS Biology},
  year={2005},
  volume={3},
  pages={152 - 179}
}
Understanding the evolution of influenza A viruses in humans is important for surveillance and vaccine strain selection. We performed a phylogenetic analysis of 156 complete genomes of human H3N2 influenza A viruses collected between 1999 and 2004 from New York State, United States, and observed multiple co-circulating clades with different population frequencies. Strikingly, phylogenies inferred for individual gene segments revealed that multiple reassortment events had occurred among these… CONTINUE READING
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References

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An influenza A(H3) reassortant was epidemic in Australia and New Zealand in 2003.

Journal of medical virology • 2005
View 6 Excerpts
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Human influenza A (H1N2) viruses isolated from China.

The Journal of general virology • 1992
View 10 Excerpts
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