Whole-Genome Analysis of 60 G Protein-Coupled Receptors in Caenorhabditis elegans by Gene Knockout with RNAi

@article{Keating2003WholeGenomeAO,
  title={Whole-Genome Analysis of 60 G Protein-Coupled Receptors in Caenorhabditis elegans by Gene Knockout with RNAi},
  author={Christopher D. Keating and Neline Kriek and Margaret J. Daniels and Neville R. Ashcroft and Neil A. Hopper and Elodie J. Siney and Lindy Holden-Dye and J. F. Burke},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={1715-1720}
}
G protein-coupled receptors (GPCRs) are the largest family of genes in animal genomes and represent more than 2% of genes in humans and C. elegans. These evolutionarily conserved seven-transmembrane proteins transduce a diverse range of signals. In view of their pivotal role in cell signaling, it is perhaps surprising that decades of genetic analysis in C. elegans, and recent genome-wide RNAi screens, have identified very few GPCR mutants. Therefore, we screened all GPCRs predicted to bind… CONTINUE READING
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