Whole-Cell Detection of C-P Bonds in Bacteria.

  title={Whole-Cell Detection of C-P Bonds in Bacteria.},
  author={Christopher S Bartlett and Sonal Bansal and Alysha Burnett and Michael D. L. Suits and Jacob Schaefer and Lynette Cegelski and Geoff P Horsman and Joel T. Weadge},
  volume={56 44},
Naturally produced molecules possessing a C-P bond, such as phosphonates and phosphinates, remain vastly underexplored. Although success stories like fosfomycin have reinvigorated small molecule phosphonate discovery efforts, bioinformatic analyses predict an enormous unexplored biological reservoir of C-P bond-containing molecules, including those attached to complex macromolecules. However, high polarity, a lack of chromophores, and complex macromolecular association impede phosphonate… CONTINUE READING
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