Who watches the watchmen? An appraisal of benchmarks for multiple sequence alignment.

  title={Who watches the watchmen? An appraisal of benchmarks for multiple sequence alignment.},
  author={Stefano A Iantorno and Kevin Gori and N. Goldman and M. Gil and C. Dessimoz},
  journal={Methods in molecular biology},
  • Stefano A Iantorno, Kevin Gori, +2 authors C. Dessimoz
  • Published 2014
  • Medicine, Computer Science, Biology
  • Methods in molecular biology
  • Multiple sequence alignment (MSA) is a fundamental and ubiquitous technique in bioinformatics used to infer related residues among biological sequences. Thus alignment accuracy is crucial to a vast range of analyses, often in ways difficult to assess in those analyses. To compare the performance of different aligners and help detect systematic errors in alignments, a number of benchmarking strategies have been pursued. Here we present an overview of the main strategies-based on simulation… CONTINUE READING

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