Who are those strangers in the Latin Square

  title={Who are those strangers in the Latin Square},
  author={Wen-ping Hsieh and Tzu-Ming Chu and Russell D. Wolfinger},
We approach the human Affymetrix Latin Square data from a classical parametric statistical modeling perspective. The first stage is to formulate a reasonable model for the probe-level data based on extant knowledge of the experimental design and technology. We present some options for this and settle on a linear mixed model for the log 2 perfect match data. Upon applying this model to the data for every gene in turn, we discover that not only do the fourteen spiked-in genes appear highly… CONTINUE READING