Whitening effect of adipose-derived stem cells: a critical role of TGF-beta 1.

@article{Kim2008WhiteningEO,
  title={Whitening effect of adipose-derived stem cells: a critical role of TGF-beta 1.},
  author={Won-Serk Kim and So-Hyun Park and S Ahn and Hyung-Ki Kim and Jeong-Soo Park and G Lee and Kea-Jeung Kim and K Whang and Seung-Hee Kang and Byung-Soon Park and Jong-Hyuk Sung},
  journal={Biological & pharmaceutical bulletin},
  year={2008},
  volume={31 4},
  pages={606-10}
}
It has been demonstrated that adipose-derived stem cells (ADSCs) secrete cytokines and exhibit diverse pharmacological actions. The present study examined the unknown pharmacological action of ADSCs regarding whitening effects. A conditioned medium of ADSCs (ADSC-CM) was harvested and the whitening effect of ADSC-CM was studied in melanoma B16 cells. ADSC-CM treatment inhibited the synthesis of melanin and the activity of tyrosinase in a dose dependent manner. To clarify the underlying… CONTINUE READING
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