Whitening Effect of Octaphlorethol A Isolated from Ishige foliacea in an In Vivo Zebrafish Model.

  title={Whitening Effect of Octaphlorethol A Isolated from Ishige foliacea in an In Vivo Zebrafish Model.},
  author={Kil-Nam Kim and Hye-Mi Yang and Sung-Myung Kang and Ginne Ahn and Seong Woon Roh and Wonwoo Lee and Dae-Kyung Kim and You-Jin Jeon},
  journal={Journal of microbiology and biotechnology},
  volume={25 4},
In a previous study, we isolated octaphlorethol A (OPA) from Ishige foliacea and evaluated its anti-melanogenesis activity in a murine melanoma cell line. However, the whitening effect and toxicity of OPA have not yet been examined in vivo. Therefore, in this study, we investigated the inhibitory effect of OPA on melanin synthesis and tyrosinase activity in an in vivo zebrafish model. More than 90% of subject embryos survived upon exposure to OPA concentrations below 25 micrometer, which was… 

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