White-matter tract integrity in late-life depression: associations with severity and cognition

@article{Charlton2013WhitematterTI,
  title={White-matter tract integrity in late-life depression: associations with severity and cognition},
  author={Rebecca Ann Charlton and Melissa Lamar and Aifeng Zhang and S Yang and Olusola Ajilore and A. Kumar},
  journal={Psychological Medicine},
  year={2013},
  volume={44},
  pages={1427 - 1437}
}
Background Although significant changes in both gray and white matter have been noted in late-life depression (LLD), the pathophysiology of implicated white-matter tracts has not been fully described. In this study we examined the integrity of specific white-matter tracts in LLD versus healthy controls (HC). Method Participants aged ⩾60 years were recruited from the community. The sample included 23 clinically diagnosed individuals with LLD and 23 HC. White-matter integrity metrics [fractional… 
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TLDR
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TLDR
This work used network dysfunction model as a conceptual framework for reviewing recent neuroimaging findings in late-life depression and focused on 4 major neurocircuits that have been shown to be involved in LLD: default mood network, cognitive control network, affective/frontolimbic network, and corticostriatal circuits.
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