White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration.

@article{Kovacs2008WhiteMT,
  title={White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration.},
  author={Gabor G Kovacs and Katalin Majt{\'e}nyi and Salvatore Spina and Jill R. Murrell and Ellen Gelp{\'i} and Romana Hoftberger and Graham Fraser and R. A. Crowther and Michel Goedert and H Budka and Bernardino Ghetti},
  journal={Journal of neuropathology and experimental neurology},
  year={2008},
  volume={67 10},
  pages={
          963-75
        }
}
Frontotemporal lobar degenerations are a group of disorders characterized by circumscribed degeneration of the frontal and temporal lobes and diverse histopathologic features. We report clinical, neuropathologic, ultrastructural, biochemical, and genetic data on 7 individuals with a 4-repeat tauopathy characterized by the presence of globular glial inclusions (GGIs) in brain white matter. Clinical manifestations were compatible with the behavioral variant of frontotemporal dementia and included… CONTINUE READING

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