White matter structural integrity in healthy aging adults and patients with Alzheimer disease: a magnetic resonance imaging study.


BACKGROUND Imaging and postmortem studies suggest that frontal lobe white matter (FLWM) volume expands until about the age of 44.6 years and then declines. Postmortem evidence indicates that the structural integrity of myelin sheaths deteriorates during normal aging, especially in late myelinating regions such as the frontal lobes. OBJECTIVES To assess… (More)

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