White matter neuron alterations in schizophrenia and related disorders.

  title={White matter neuron alterations in schizophrenia and related disorders.},
  author={Caroline Martine Connor and Benjamin C Crawford and Schahram Akbarian},
  journal={International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience},
  volume={29 3},
Increased density and altered spatial distribution of subcortical white matter neurons (WMNs) represents one of the more well replicated cellular alterations found in schizophrenia and related disease. In many of the affected cases, the underlying genetic risk architecture for these WMN abnormalities remains unknown. Increased density of neurons immunoreactive for Microtubule-Associated Protein 2 (MAP2) and Neuronal Nuclear Antigen (NeuN) have been reported by independent studies, though there… CONTINUE READING
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