White matter microstructure in late middle-age: Effects of apolipoprotein E4 and parental family history of Alzheimer's disease

@inproceedings{Adluru2014WhiteMM,
  title={White matter microstructure in late middle-age: Effects of apolipoprotein E4 and parental family history of Alzheimer's disease},
  author={Nagesh Adluru and Daniel J. Destiche and Sharon Yuan-Fu Lu and Samuel T. Doran and Alex Cole Birdsill and Kelsey E. Melah and Ozioma C. Okonkwo and Andrew L. Alexander and N. Maritza Dowling and Sterling C. Johnson and Mark A. Sager and Barbara B. Bendlin},
  booktitle={NeuroImage: Clinical},
  year={2014}
}
INTRODUCTION Little is still known about the effects of risk factors for Alzheimer's disease (AD) on white matter microstructure in cognitively healthy adults. The purpose of this cross-sectional study was to assess the effect of two well-known risk factors for AD, parental family history and APOE4 genotype. METHODS This study included 343 participants from the Wisconsin Registry for Alzheimer's Prevention, who underwent diffusion tensor imaging (DTI). A region of interest analysis was… CONTINUE READING

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