White matter lesions in Parkinson disease

  title={White matter lesions in Parkinson disease},
  author={Nicolaas I. Bohnen and Roger L Albin},
  journal={Nature Reviews Neurology},
Pure vascular parkinsonism without evidence of nigral Lewy body pathology may occur as a distinct clinicopathological entity, but a much more frequent occurrence is the comorbid presence of age-associated white matter lesions (WMLs) in idiopathic Parkinson disease (PD). WMLs are associated with motor and cognitive symptoms in otherwise normal elderly individuals. Comorbid WMLs are, therefore, expected to contribute to clinical symptoms in PD. Studies of WMLs in PD differ with regard to methods… CONTINUE READING


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