White matter lesions impair frontal lobe function regardless of their location

@article{Tullberg2004WhiteML,
  title={White matter lesions impair frontal lobe function regardless of their location},
  author={Mats Tullberg and Evan Fletcher and Charles DeCarli and Dan Mungas and Bruce R. Reed and Danielle J. Harvey and Michael W Weiner and Helena Chui and William J. Jagust},
  journal={Neurology},
  year={2004},
  volume={63},
  pages={246 - 253}
}
Objective: To analyze the effect of white matter lesions in different brain regions on regional cortical glucose metabolism, regional cortical atrophy, and cognitive function in a sample with a broad range of cerebrovascular disease and cognitive function. Methods: Subjects (n = 78) were recruited for a study of subcortical ischemic vascular disease (SIVD) and Alzheimer disease (AD) contributions to dementia. A new method was developed to define volumes of interest from high-resolution three… 

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