White matter imaging contributes to the multimodal diagnosis of frontotemporal lobar degeneration.

@article{McMillan2012WhiteMI,
  title={White matter imaging contributes to the multimodal diagnosis of frontotemporal lobar degeneration.},
  author={Corey T McMillan and Charlotte Brun and Saima Siddiqui and Matthew A Churgin and David J. Libon and Paul A. Yushkevich and Hong-Liang Zhang and Ashley Boller and James Gee and Murray Grossman},
  journal={Neurology},
  year={2012},
  volume={78 22},
  pages={
          1761-8
        }
}
OBJECTIVE To evaluate the distribution of white matter (WM) disease in frontotemporal lobar degeneration (FTLD) and Alzheimer disease (AD) and to evaluate the relative usefulness of WM and gray matter (GM) for distinguishing these conditions in vivo. METHODS Patients were classified as having FTLD (n = 50) or AD (n = 42) using autopsy-validated CSF values of total-tau:β-amyloid (t-tau:Aβ(1-42)) ratios. Patients underwent WM diffusion tensor imaging (DTI) and volumetric MRI of GM. We employed… CONTINUE READING

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