White matter hyperintensity on magnetic resonance imaging: clinical and neuroanatomic correlates in the depressed elderly.

@article{Coffey1989WhiteMH,
  title={White matter hyperintensity on magnetic resonance imaging: clinical and neuroanatomic correlates in the depressed elderly.},
  author={Charles E. Coffey and Gary S. Figiel and W T Djang and William B. Saunders and Richard D. Weiner},
  journal={The Journal of neuropsychiatry and clinical neurosciences},
  year={1989},
  volume={1 2},
  pages={135-44}
}
In a prospective study of depressed elderly patients referred for electroconvulsive therapy (ECT), subcortical white matter hyperintensity (WMH) was seen in all 51 patients 60 years or older who received magnetic resonance imaging (MRI) prior to treatment. In over half of the patients the WMH was formally rated as at least moderately severe, and it was commonly associated with other structural brain changes. The majority (80%) of patients had late-age-onset depression, suggesting that… CONTINUE READING

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