White matter hyperintensities and normal-appearing white matter integrity in the aging brain

@inproceedings{Maniega2015WhiteMH,
  title={White matter hyperintensities and normal-appearing white matter integrity in the aging brain},
  author={Susana Mu{\~n}oz Maniega and Maria Del C Vald{\'e}s Hern{\'a}ndez and Jonathan D. Clayden and Natalie A. Royle and Catherine A. Murray and Zoe Slote Morris and Benjamin S. Aribisala and Alan J. Gow and John M. Starr and Mark E. Bastin and Ian J. Deary and Joanna M. Wardlaw},
  booktitle={Neurobiology of Aging},
  year={2015}
}
White matter hyperintensities (WMH) of presumed vascular origin are a common finding in brain magnetic resonance imaging of older individuals and contribute to cognitive and functional decline. It is unknown how WMH form, although white matter degeneration is characterized pathologically by demyelination, axonal loss, and rarefaction, often attributed to ischemia. Changes within normal-appearing white matter (NAWM) in subjects with WMH have also been reported but have not yet been fully… CONTINUE READING
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