White matter hyperintensities and cognitive performance in adult patients with bipolar I, bipolar II, and major depressive disorders.

@article{Kiesepp2014WhiteMH,
  title={White matter hyperintensities and cognitive performance in adult patients with bipolar I, bipolar II, and major depressive disorders.},
  author={Tuula Kiesepp{\"a} and Riitta M{\"a}ntyl{\"a} and Annamari Tuulio-Henriksson and Katariina Luoma and Outi K Mantere and Mikko Ketokivi and Mikael K Holma and Pekka J Jylh{\"a} and Tarja Melartin and Kirsi H. Suominen and Maria S Vuorilehto and Erkki Isomets{\"a}},
  journal={European psychiatry : the journal of the Association of European Psychiatrists},
  year={2014},
  volume={29 4},
  pages={226-32}
}
PURPOSE We evaluate for the first time the associations of brain white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) with neuropsychological variables among middle-aged bipolar I (BPI), II (BPII) and major depressive disorder (MDD) patients and controls using a path model. METHODS Thirteen BPI, 15 BPII, 16 MDD patients, and 21 controls underwent brain MRI and a neuropsychological examination. Two experienced neuroradiologists evaluated WMHs on the MRI scans. We… CONTINUE READING
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