White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study.

@article{Kuller2007WhiteMG,
  title={White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study.},
  author={Lewis H. Kuller and Alice M. Arnold and William T. Longstreth and Teri Manolio and Daniel H. O'Leary and Gregory L Burke and Linda P. Fried and Anne B. Newman},
  journal={Neurobiology of aging},
  year={2007},
  volume={28 9},
  pages={1307-15}
}
High white matter grade (WMG) on magnetic resonance imaging (MRI) is a risk factor for dementia, stroke and disability. Higher ventricular size is a marker of brain "atrophy." In the Cardiovascular Health Study (CHS) (n=3245) mean age 75 years, 50% black and 40% men, we evaluated WM and ventricular grade (VG), total, cardiovascular and noncardiovascular mortality and longevity before and after adjusting for numerous determinants of longevity over an approximate 10-12 years of follow-up. A low… CONTINUE READING