White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease

  title={White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease},
  author={Miguel {\'A}ngel Araque Caballero and Marc Su{\'a}rez-Calvet and Marco Duering and Nicolai Franzmeier and Tammie L.-S. Benzinger and Anne M Fagan and Randall J. Bateman and Clifford R. Jack and Johannes Levin and Martin Dichgans and Mathias Jucker and Celeste M. Karch and Colin L. Masters and John C. Morris and Michael Weiner and Martin N. Rossor and Nick C Fox and Jae-Hong Lee and Stephen P. Salloway and Adrian Danek and Alison M. Goate and Igor Yakushev and Jason Hassenstab and Peter R. Schofield and Christian Haass and Michael Ewers},
  pages={3065 - 3080}
See Jacobs and Buckley (doi:10.1093/brain/awy243) for a scientific commentary on this article. Despite the prevalence of white matter alterations in Alzheimer's disease, their occurrence in the presymptomatic phase is poorly understood. Araque-Caballero et al. report that diffusivity alterations occur first within the anterior and posterior callosal fibres approximately 10 years before the onset of dementia symptoms in autosomal dominant Alzheimer's disease. 

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