White matter correlates of adolescent depression: structural evidence for frontolimbic disconnectivity.

@article{Lewinn2014WhiteMC,
  title={White matter correlates of adolescent depression: structural evidence for frontolimbic disconnectivity.},
  author={Kaja Z Lewinn and Colm G Connolly and Jing Wu and Miroslav Drahos and Fumiko Hoeft and Tiffany C. Ho and Alan N. Simmons and Tony T. Yang},
  journal={Journal of the American Academy of Child and Adolescent Psychiatry},
  year={2014},
  volume={53 8},
  pages={899-909, 909.e1-7}
}
OBJECTIVE Despite the significant prevalence of adolescent depression, little is known about the neuroanatomical basis of this disorder. Functional dysregulation in frontolimbic circuitry has been suggested as a key neural correlate of adult and adolescent depression impeding emotional regulation. However, less is known about whether this dysregulation is overlaid on impaired white matter microstructure. Guided by neuroimaging findings, we test the a priori hypotheses that adolescent depression… CONTINUE READING
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