White-matter changes on MRI as surrogate marker.


This article reviews the use of white-matter changes as identified on MRI as a surrogate marker in clinical trials on vascular dementia. As of yet, insufficient evidence is present to implement rating or volumetric assessment of the burden of white-matter changes as surrogate marker in such trials, in view of the limited sensitivity to change of current methods and the high measurement error.


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@article{Scheltens2003WhitematterCO, title={White-matter changes on MRI as surrogate marker.}, author={Philip Scheltens and Frederik Barkhof and Franz Fazekas}, journal={International psychogeriatrics}, year={2003}, volume={15 Suppl 1}, pages={261-5} }