White matter changes in HIV-1 infected brains: a combined gross anatomical and ultrastructural morphometric investigation of the corpus callosum.

@article{Wohlschlaeger2009WhiteMC,
  title={White matter changes in HIV-1 infected brains: a combined gross anatomical and ultrastructural morphometric investigation of the corpus callosum.},
  author={Jeremias Wohlschlaeger and Elisabeth Wenger and Parviz Mehraein and Serge Weis},
  journal={Clinical neurology and neurosurgery},
  year={2009},
  volume={111 5},
  pages={422-9}
}
OBJECTIVE The HIV-1 associated cognitive/motor complex is characterized by cognitive, motor and behavioral disturbances. Besides a significant loss of neurons in the cerebral cortex and subcortical nuclei, a possible morphological substrate of this complex is also given by changes of the white matter as seen in HIV-1 leucoencephalopathy (HIVL), which is characterized by widespread diffuse pallor of myelin and the presence of gliomesenchymal nodules with multinucleated giant cells. METHODS The… CONTINUE READING

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