White matter alterations in Parkinson’s disease with normal cognition precede grey matter atrophy

Abstract

INTRODUCTION While progressive MRI brain changes characterize advanced Parkinson's disease (PD), little has been discovered about structural alterations in the earliest phase of the disease, i.e. in patients with motor symptoms and with normal cognition. Our study aimed to detect grey matter (GM) and white matter (WM) changes in PD patients without… (More)
DOI: 10.1371/journal.pone.0187939

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