White matter abnormalities and executive function in children with very low birth weight.


The aim of this study was to investigate any structural-functional relationship between changes in white matter microstructure seen on diffusion tensor imaging and results of an executive function test in adolescents with very low birth weight (VLBW). Thirty-four VLBW adolescents were examined at 15 years of age. Executive function was assessed by the Wisconsin Card Sorting Test. Diffusion tensor imaging scans were performed at 1.5 T for calculation of individual fractional anisotropy maps. Through a voxel-wise regression analysis, correlations were found between the results on Wisconsin Card Sorting Test and fractional anisotropy values in the left cingulum and both inferior fronto-occipital fascicles. We speculate that impairments in executive function in VLBW children may be influenced by disturbed connectivity between posterior brain regions and the prefrontal cortex.

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@article{Skranes2009WhiteMA, title={White matter abnormalities and executive function in children with very low birth weight.}, author={Jon Skranes and Gro C Lohaugen and Marit Petra Martinussen and Marit S{\ae}b\o Indredavik and Anders M. Dale and Olav Haraldseth and T R Vangberg and Ann-Mari Brubakk}, journal={Neuroreport}, year={2009}, volume={20 3}, pages={263-6} }