White matter: beyond focal disconnection.

  title={White matter: beyond focal disconnection.},
  author={Christopher M. Filley},
  journal={Neurologic clinics},
  volume={29 1},
  pages={81-97, viii}
The complex phenomenology of white matter dementia and many neuropsychiatric disorders implies that they originate from involvement of distributed neural networks, and white matter neuropathology is increasingly implicated in the pathogenesis of these network disconnection syndromes. White matter disorders produce functional asynchrony of interdependent cerebral regions subserving normal cognitive and emotional functions. Accumulating evidence suggests that white matter dementia primarily… CONTINUE READING
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