White cell fragmentation after therapeutic leukapheresis for acute leukemia.

@article{Rybroek1987WhiteCF,
  title={White cell fragmentation after therapeutic leukapheresis for acute leukemia.},
  author={J J van Rybroek and John P. Olson and Chapala P. Burns},
  journal={Transfusion},
  year={1987},
  volume={27 4},
  pages={353-5}
}
A 70-year-old woman with newly diagnosed acute nonlymphocytic leukemia (FAB M5) underwent therapeutic leukapheresis because of a white cell count (WBC) of 144 X 10(9) per I and clinical evidence of leukostasis. A peripheral blood film taken immediately after leukapheresis showed numerous cytoplasmic and nuclear fragments. The patient's clinical course thereafter was significantly compromised by disseminated intravascular coagulation with a severe bleeding diathesis, renal failure, and… CONTINUE READING