• Corpus ID: 15855369

White Shaker Disease Syndrome

  title={White Shaker Disease Syndrome},
  author={Lindsey Buracker and John Robertson},
White Shaker Disease Syndrome (WSDS) is a neurologic disease seen primarily in dogs with white coats, particularly in West Highland White Terriers, Maltese Terriers (Bagley, et al., 1993), and Samoyeds (Cummings, et al., 1986). The disease presents with a very unique generalized tremor, in young (5 months to 3 years old) dogs of either gender (Yamaya, et al., 2004). The National Institutes of Neurological Disorders and Stroke defines tremor as “unintentional, somewhat rhythmic, muscle movement… 


A case of shaker dog disease in a miniature dachshund.
This case with brown hair with paroxysmal generalized tremors was diagnosed as the shaker dog disease, which has also been well known as "little white shakers" syndrome due to being found in small dogs with white hair, because the clinical signs were exactly analogous to the shake dog disease.
Globoid cell leukodystrophy in cairn and West Highland white terriers.
Through a screening test based on the molecular defect found in these breeds, over 50 cairn terrier carriers have been identified and a colony of five carrier dogs has been established and successful treatment of this canine model will lead to studies in some humans with GLD.
MRI and electrophysiological abnormalities in a case of canine globoid cell leucodystrophy.
Electrodiagnostic testing revealed evidence of peripheral neuropathy and an abnormal brainstem auditory evoked response that may raise the suspicion of GCL in dogs and may aid in monitoring disease progression.
Clinical signs and neuropathologic abnormalities in working Australian Kelpies with globoid cell leukodystrophy (Krabbe disease).
The demyelination, inflammatory responses, and axo-nal spheroids evident in the AWKs were consistent with the clinical signs of peripheral nerve, spinal cord, and cerebellar dysfunction.
Krabbe's disease in two West Highland White terriers.
The diagnosis of Krabbe's disease was performed based on the clinical evaluation, morphological, histochemical and ultrastructural features, and a method involving PCR amplification of genomic DNA followed by restriction-digestion was used.
Tremors in Samoyed pups with oligodendrocyte deficiencies and hypomyelination
A breeder of Samoyed dogs observed six litters in which one or more pups at 3 weeks of age showed generalized tremors and an inability to stand, suggesting that this hypomyelination was the result of retarded gliogenesis.
Degenerative Diseases of the Central Nervous System *
The focus of occupational therapy related to the treatment of degenerative diseases is understood and the occupational therapy interventions used to treat clients with degenerative disease across the various stages of the disease are recognized.
The morphologic similarities of human and canine globoid leukodystrophy. Thin section and freeze-fracture studies.
Human and canine globoid leukodystrophy are shown to be indistinguishable morphologically. Both have characteristic deposits with polygonal cross-sectional profiles in addition to twisted ribbon-like