White Matter Tractography in Bipolar Disorder and Schizophrenia

@article{McIntosh2008WhiteMT,
  title={White Matter Tractography in Bipolar Disorder and Schizophrenia},
  author={Andrew M. McIntosh and Susana Mu{\~n}oz Maniega and G. Katherine S. Lymer and James W. McKirdy and Jeremy Hall and Jessika E. Sussmann and Mark E. Bastin and Jonathan D. Clayden and Eve C. Johnstone and Stephen M. Lawrie},
  journal={Biological Psychiatry},
  year={2008},
  volume={64},
  pages={1088-1092}
}

Assessment of white matter abnormalities in paranoid schizophrenia and bipolar mania patients

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The results show that a shared white-matter dysconnectivity links the two major psychotic disorders, and microstructural abnormalities predict functional outcome better than symptom-based diagnostic boundaries during a clinically stable phase of illness.

Shared and distinct white matter abnormalities in schizophrenia and bipolar disorder

Abnormal frontal cortex white matter connections in bipolar disorder: a DTI tractography study.

Similar white matter changes in schizophrenia and bipolar disorder: A tract-based spatial statistics study

This is the first study applying TBSS on all the DTI indexes at the same time in both patient groups showing that they share similar impairments in microstructural connectivity, with particular regards to fronto-temporal and callosal communication, which are likely to worsen over time.

Myelin vs Axon Abnormalities in White Matter in Bipolar Disorder

It is suggested that patients with BDP exhibit reduced myelin content, but no changes in axon geometry compared with controls, in contrast with recent findings in patients with schizophrenia (SZ), which suggest both myelination and axon abnormalities in SZ.

A multicenter tractography study of deep white matter tracts in bipolar I disorder: psychotic features and interhemispheric disconnectivity.

In this multicenter sample of bipolar I disorder patients, BPI patients had reduced WM integrity in interhemispheric, limbic, and arcuate WM tracts, highlighting the existence of an anatomic disconnectivity in BPI and underscoring a role for interhemipheric disconnectedivity in the pathophysiological features of psychosis.
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