White Matter Tractography in Bipolar Disorder and Schizophrenia

  title={White Matter Tractography in Bipolar Disorder and Schizophrenia},
  author={Andrew M. McIntosh and Susana Mu{\~n}oz Maniega and G. Katherine S. Lymer and James W. McKirdy and Jeremy Hall and Jessika E. Sussmann and Mark E. Bastin and Jonathan D. Clayden and Eve C. Johnstone and Stephen M. Lawrie},
  journal={Biological Psychiatry},

Assessment of white matter abnormalities in paranoid schizophrenia and bipolar mania patients

Shared white-matter dysconnectivity in schizophrenia and bipolar disorder with psychosis

The results show that a shared white-matter dysconnectivity links the two major psychotic disorders, and microstructural abnormalities predict functional outcome better than symptom-based diagnostic boundaries during a clinically stable phase of illness.

Shared and distinct white matter abnormalities in schizophrenia and bipolar disorder

Abnormal frontal cortex white matter connections in bipolar disorder: a DTI tractography study.

Similar white matter changes in schizophrenia and bipolar disorder: A tract-based spatial statistics study

This is the first study applying TBSS on all the DTI indexes at the same time in both patient groups showing that they share similar impairments in microstructural connectivity, with particular regards to fronto-temporal and callosal communication, which are likely to worsen over time.

Myelin vs Axon Abnormalities in White Matter in Bipolar Disorder

It is suggested that patients with BDP exhibit reduced myelin content, but no changes in axon geometry compared with controls, in contrast with recent findings in patients with schizophrenia (SZ), which suggest both myelination and axon abnormalities in SZ.

A multicenter tractography study of deep white matter tracts in bipolar I disorder: psychotic features and interhemispheric disconnectivity.

In this multicenter sample of bipolar I disorder patients, BPI patients had reduced WM integrity in interhemispheric, limbic, and arcuate WM tracts, highlighting the existence of an anatomic disconnectivity in BPI and underscoring a role for interhemipheric disconnectedivity in the pathophysiological features of psychosis.



Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study.

The findings suggest that a loss of bundle coherence is present in prefrontal white matter that may contribute to prefrontal cortical pathology in patients with bipolar disorder.

Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study

The findings of reduced white matter tract integrity in the left uncinate fasciculus and left arcuate fascicule suggest that there is frontotemporal and frontoparietal structural disconnectivity in schizophrenia.

Structural abnormalities of ventrolateral and orbitofrontal cortex in patients with familial bipolar disorder.

Abnormalities of the ventral prefrontal cortex are likely to be involved in the aetiopathology of bipolar disorder, while hallucinations appear to be more closely associated with temporal lobe abnormality, extending earlier work in schizophrenia.

Genetic liability to schizophrenia or bipolar disorder and its relationship to brain structure

  • A. McIntoshD. Job S. Lawrie
  • Psychology, Medicine
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2006
Genes that raise the likelihood of developing schizophrenia may exert their effects by diminishing grey matter volume in the D LPFC and VLPFC and their associated white matter connections by diminishing the volume of grey matter in dorso‐ (DLPFC) and ventrolateral prefrontal (VLPFC) cortices.

Functional disconnectivity in subjects at high genetic risk of schizophrenia.

The results, all in a situation uncontaminated by the effects of anti-psychotic medication, performance differences and prolonged illness, suggest there are abnormalities in functional connectivity over and above those attributable to task effects in high risk subjects.

Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes.

Investigating the relationship between genetic risk and structural variation throughout the entire brain in patients and their unaffected relatives sampled from multiply affected families with schizophrenia or bipolar disorder found the 2 major psychoses show both distinctive and similar patterns of brain structural abnormality related to variable genetic risk.

Reduction of the Internal Capsule in Families Affected with Schizophrenia