White Matter Tract Alterations in Drug-Naïve Parkinson's Disease Patients With Excessive Daytime Sleepiness

@article{AshrafGanjouei2019WhiteMT,
  title={White Matter Tract Alterations in Drug-Na{\"i}ve Parkinson's Disease Patients With Excessive Daytime Sleepiness},
  author={Amir Ashraf-Ganjouei and Ghazaleh Kheiri and Maryam Masoudi and Bahram Mohajer and Mahtab Mojtahed Zadeh and Pejman Saberi and Mehdi Shirin Shandiz and Mohammad Hadi Aarabi},
  journal={Frontiers in Neurology},
  year={2019},
  volume={10}
}
Excessive daytime sleepiness (EDS) is relatively frequent in patients with Parkinson's disease (PD), having a prominent burden on patients' quality of life and causing dangerous events such as motor-vehicle accidents. Previous studies have indicated the role of certain neural tracts in the pathophysiology of sleep disturbances, especially in PD patients. We hypothesized that white matter integrity and connectivity might be altered in patients with PD and EDS. Therefore, this study investigated… 

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References

SHOWING 1-10 OF 59 REFERENCES

Widespread cortical and subcortical brain atrophy in Parkinson’s disease with excessive daytime sleepiness

Regional brain atrophy was assessed in Parkinson’s disease patients with excessive daytime sleepiness using voxel-based morphometry with 3-T magnetic resonance imaging and patients with EDS showed significant gray matter atrophy compared to patients without EDS and controls.

Disruptions of the fornix fiber in Parkinsonian patients with excessive daytime sleepiness.

Multimodal imaging evaluation of excessive daytime sleepiness in Parkinson's disease

The study findings support the contribution of the total dopaminergic load in the development of EDS, while the dose of dopamine agonists was found to predict the severity of the disorder.

Excessive daytime sleepiness may be associated with caudate denervation in Parkinson disease

Microstructural changes in patients with Parkinson disease and REM sleep behavior disorder: depressive symptoms versus non-depressed

Diffusivity alteration of the mentioned fibers in depressed, early PD patients with RBD might reflect underlying PD pathology and serve as common structural DWI signatures for early PD diagnosis.

Excessive daytime sleepiness in Parkinson disease: a SPECT study.

The cortical hypofunction relative to hyperfunction of the brain stem may relate to EDS in Parkinson disease, and further studies are required.

Progressive dopamine and hypocretin deficiencies in Parkinson’s disease: is there an impact on sleep and wakefulness?

Comparing sleep laboratory tests and cerebrospinal fluid levels with hypocretin‐deficient patients with narcolepsy with cataplexy, and with matched controls suggests that dopamine and hypoc retin deficiency differentially affect sleep and wakefulness in Parkinson’s disease.

Excessive Daytime Sleepiness in Patients with Parkinson’s Disease

The efficacy of pharmacological treatment of EDS in Parkinson’s disease using wakefulness-promoting drugs such as modafinil remains controversial, and further areas of research are now also focusing on adenosine A2A receptor antagonists, sodium oxybate and caffeine to promote wakefulness.
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