White Matter Damage Disorganizes Brain Functional Networks in Amnestic Mild Cognitive Impairment

  title={White Matter Damage Disorganizes Brain Functional Networks in Amnestic Mild Cognitive Impairment},
  author={Jos{\'e} Angel Pineda-Pardo and Pilar Garc{\'e}s and Mar{\'i}a Eugenia L{\'o}pez and Sara Aurtenetxe and Pablo Cuesta and Alberto Marcos and Pedro Montejo and Miguel Yus and Juan Antonio Hern{\'a}ndez Tamames and Francisco del Pozo and James T. Becker and Fernando Maest{\'u}},
  journal={Brain connectivity},
  volume={4 5},
Although progressive functional brain network disruption has been one of the hallmarks of Alzheimer's Disease, little is known about the origin of this functional impairment that underlies cognitive symptoms. We investigated how the loss of white matter (WM) integrity disrupts the organization of the functional networks at different frequency bands. The analyses were performed in a sample of healthy elders and mild cognitive impairment (MCI) subjects. Spontaneous brain magnetic activity… CONTINUE READING
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