White Matter Changes in OCD Revealed by Diffusion Tensor Imaging

  title={White Matter Changes in OCD Revealed by Diffusion Tensor Imaging},
  author={Leonardo Franklin Fontenelle and Ivanei E. Bramati and Jorge Moll and Mauro Vitor Mendlowicz and Ricardo de Oliveira-Souza and Fernanda Tovar-Moll},
  journal={CNS Spectrums},
  pages={101 - 109}
Abstract Introduction The aim of this study was to investigate white matter (WM) abnormalities in obsessive-compulsive disorder (OCD) and its relationship to severity of obsessive-compulsive symptoms. Methods Conventional and diffusion tensor imaging were acquired in nine patients with OCD and nine gender- and age-matched healthy volunteers. Changes in fractional anisotropy (FA) and mean diffusivity (MD) were investigated using selected regions of interest (ROIs) analyses and whole brain tract… 
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The study results provide further evidence for OCD-related white matter abnormalities in the ALIC and cingulum, consistent with a cortico striatal model of OCD.
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An MRI Study of the Metabolic and Structural Abnormalities in Obsessive-Compulsive Disorder
The findings reinforce the involvement of CSTC bundles in pathophysiology of OCD, pointing to a specific role of glutamate (glutamine) and WM integrity.
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White matter microstructural and Compulsive Sexual Behaviors Disorder – Diffusion Tensor Imaging study
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A pattern of greater directional coherence of white matter tracts in OCD very early in the course of illness is suggested, which may serve a compensatory mechanism, at least for response inhibition functions typically subserved by the cingulum bundle.
Mélanie Fernandes Gonçalves
The main objective of the present study is to analyze white matter architecture in patients with obsessive-compulsive personality disorder. Using diffusion tensor imaging techniques, together with a


A diffusion tensor imaging study of white matter in obsessive–compulsive disorder
FA differences in these areas are consistent with the presence of abnormal connections between the nodes linked by these tracts, which could explain why surgically severing these tracts is therapeutic.
White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study.
Preliminary findings provide evidence of an abnormality that involves the anterior cingulate white matter in the pathogenesis of OCD and are consistent with neurobiological models that posit a defect in connectivity in the anteriorcingulate basal ganglia-thalamocortical circuit.
Corpus callosum in patients with obsessive-compulsive disorder: diffusion-tensor imaging study.
Study results support the widely held view that the orbital prefrontal region is involved in the pathophysiology of OCD and indicate that the orbitofrontal circuit influences symptom severity in patients with OCD.
Meta-Analysis of Brain Volume Changes in Obsessive-Compulsive Disorder