Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice

@article{Li1994WhiskerrelatedNP,
  title={Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice},
  author={Yuqing Li and Reha S. Erzurumlu and Chong Chen and Sonal Jhaveri and Susumu Tonegawa},
  journal={Cell},
  year={1994},
  volume={76},
  pages={427-437}
}
NMDA Receptor-Dependent Refinement of Somatotopic Maps
Patterning of the Somatosensory Maps with NMDA Receptors
TLDR
Analysis of the phenotypes of mice with various types of NMDA receptor (NMDAR) subunit mutations as they relate to the development and patterning of somatosensory pathways shows that NMDAR signaling is necessary for dendritic and axonal pruning andpatterning.
Thalamic NMDA Receptor Function Is Necessary for Patterning of the Thalamocortical Somatosensory Map and for Sensorimotor Behaviors
TLDR
Results show that thalamic NMDARs play a critical role in the patterning of the somatosensory thalamus and cortical maps and their impairment may lead to pronounced behavioral defects.
Absence of Whisker-Related Pattern Formation in Mice with NMDA Receptors Lacking Coincidence Detection Properties and Calcium Signaling
TLDR
The results show that coincidence detection by, and/or Ca2+ permeability of, NMDARs is necessary for the development of somatotopic maps in the brainstem and suggest that highly specific signaling underlies synaptic refinement.
Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex
TLDR
It is indicated that cortical NMDARs are essential for the aggregation of layer IV cells into barrels and for development of the full complement of thalamocortical patterns.
Synaptic Ras GTPase Activating Protein Regulates Pattern Formation in the Trigeminal System of Mice
TLDR
It is demonstrated that SynGAP, a synaptic Ras GTPase activating protein, is essential for the anatomical development of whisker-related patterns in the developing somatosensory pathways in rodent forebrain, indicating that the intracellular pathways by which NMDA receptor activation mediates map formation differ between brain regions and developmental stage.
NMDA Receptor-Dependent Regulation of Axonal and Dendritic Branching
TLDR
It is shown that in NR1 gene knock-down (KD) and knock-out mice, whisker afferents begin their embryonic development normally but, over time, fail to segregate into patches, and instead they develop exuberant terminal arbors spanning most of the PrV.
Formation of Whisker-Related Principal Sensory Nucleus-Based Lemniscal Pathway Requires a Paired Homeodomain Transcription Factor, Drg11
TLDR
It is shown that mice lacking Drg11, a homeodomain transcription factor, exhibit defects within the principal sensory nucleus (PrV) of the trigeminal nerve, which lead to the failure to develop whisker-related patterns in the PrV, VPm, and somatosensory cortex.
Molecular determinants of the face map development in the trigeminal brainstem.
TLDR
Studies of neurotrophins, multiple axon guidance molecules, transcription factors, and glutamate receptors during early development of trigeminal connections between the whiskers and the brainstem that lead to emergence of patterned face maps are described and reviewed.
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References

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Effects of neonatal whisker lesions on mouse central trigeminal pathways
TLDR
Whether subcortical projections are susceptible to whisker damage in a sequence which parallels other described developmental sequences, as has been concluded from previous work on the mouse, and whether the “critical periods” are related to other aspects of development.
Evidence for prenatal competition among the central arbors of trigeminal primary afferent neurons
TLDR
Competitive interactions among the central arbors of trigeminal primary afferents in fetal life may influence the development of central vibrissa representations and, further, that lesion-induced central changes need not be correlated with alterations in the peripheral innervation of undamaged follicles.
N-methyl-D-aspartate receptor antagonists disrupt the formation of a mammalian neural map.
TLDR
Results indicate that, at a stage preceding visually evoked activity, normal NMDA receptor function is important for the development of an ordered neural map in the mammalian brain.
Two Phases of Pattern Formation in the Developing Rodent Trigeminal System
TLDR
This chapter reviews the studies on pattern formation in the trigeminal system within the context of the conferring of axial orientation of the somatotopic map in the CNS and the emergence of modular patterning within this map.
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TLDR
It is concluded that p-chloroamphetamine (PCA) treatment does not prevent formation of a vibrissa-specific pattern by thalamocortical afferents, and the possibility that the 5-HT axons may play a trophic role in the maturation of VB Afferents is discussed.
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TLDR
It is concluded that thalamic axons convey the blueprint of the sensory periphery onto the neocortex and that ECM molecules do not participate in the initial formation of this pattern.
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  • D. Stainier, W. Gilbert
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1990
TLDR
The results show the existence of an early set of axonal tracts in the mouse peripheral nervous system that may be used for the guidance of later-differentiating neurons.
Vibrissae representation in subcortical trigeminal centers of the neonatal rat
TLDR
Examination of patterns of segmentation in the neuropil of the spinal and principal trigeminal nuclei of the brainstem and in the ventrobasal complex of the thalamus reveals that the large mystacial vibrissae and sinus hairs on the face of the young rat are somatotopically represented three times.
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