Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2/alternatively activated macrophages.

@article{Desnues2005WhippleDI,
  title={Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2/alternatively activated macrophages.},
  author={Beno{\^i}t Desnues and Hubert L{\'e}pidi and Didier Raoult and J M Mege},
  journal={The Journal of infectious diseases},
  year={2005},
  volume={192 9},
  pages={
          1642-6
        }
}
Whipple disease (WD) is a rare systemic disease caused by Tropheryma whipplei and is characterized by the presence of foamy macrophages with periodic acid-Schiff-positive inclusions in tissues such as lamina propria. For the first time, we report the gene-expression profile of macrophages in intestinal lesions from a patient with WD. Microarray and real-time polymerase chain reaction revealed that genes encoding CCL18, cathepsins, scavenger receptor, interleukin-10, and lipid metabolites were… CONTINUE READING
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