Whipple's disease without malabsorption: new atypical features.

  title={Whipple's disease without malabsorption: new atypical features.},
  author={S A Misbah and B Ozols and Andrea R Franks and Nicholas Mapstone},
  journal={QJM : monthly journal of the Association of Physicians},
  volume={90 12},
The diagnosis of Whipple's disease in the absence of intestinal involvement is difficult and often overlooked. We describe five patients aged 8-71 years with normal jejunal biopsies and disparate clinical features, previously unrecognized in Whipple's; all were investigated at a single institution over a period of 18 months. Routine histological examination for periodic acid-Schiff (PAS) positive macrophages and polymerase chain reaction (PCR) analysis for Tropheryma whippelii was performed on… CONTINUE READING