Whipple's disease: staging and monitoring by cytology and polymerase chain reaction analysis of cerebrospinal fluid.

@article{Herbay1997WhipplesDS,
  title={Whipple's disease: staging and monitoring by cytology and polymerase chain reaction analysis of cerebrospinal fluid.},
  author={Axel von Herbay and H J Ditton and Frank Schuhmacher and M. Maiwald},
  journal={Gastroenterology},
  year={1997},
  volume={113 2},
  pages={434-41}
}
BACKGROUND & AIMS Diagnostic procedures in Whipple's disease usually focus on the intestine, but symptomatic central nervous system involvement is a major threat for patients. The aim of this study was to determine the diagnostic value of cerebrospinal fluid (CSF) analysis. METHODS A total of 39 CSF samples and 2 brain biopsy specimens that were obtained from 24 patients with Whipple's disease at various intervals after diagnosis were examined. Five patients presented with neurological… CONTINUE READING